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Colloquium- Prof. Andre Isaacs
Dec 6, 2024
03:30 PM - 04:20 PM
Pappajohn Business Building, W151
21 East Market Street, Iowa City, IA 52245
Andre Isaacs- Associate Professor, College of the Holy Cross
https://www.holycross.edu/academics/programs/chemistry/faculty/andre-k-i...
https://www.isaacslab.com/
"A Click Chemistry Approach to N-Heterocycles"
My research interest is centered on a very reliable organic reaction - the copper-catalyzed cycloaddition of sulfonyl azides and terminal alkynes (CuAAC). Differential fragmentation of the resulting 1,2,3-triazole generates ketenimines or rhodium carbenoids which readily engage with a variety of nucleophiles to provide access to heterocycles of interest to the synthetic community. We’ve demonstrated the utility of click chemistry in the synthesis of N-Heterocycles such as indolizines, dihydroisoquinolines and as an approach to beta-lactams.
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